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From United Kingdom:

My daughter is currently in the hospital on a sliding scale (been there a week now). She seems to have lost control of her blood sugar. Before she went in the hospital, we increased her insulin doses by over double her normal. She still reads off the scale on her meter. In the hospital, her insulin is going direct into a canula (arm). She seems to come down during the afternoon on 12 units of insulin. By mid evening she can be down to a reading of 13 mmol/L [234 mg/dl], insulin is dropped to four units and then she may go low during the night. Her numbers then go up during the day. Doctors have had problems getting a canula in her arms so they are putting one into her shoulder. While waiting for this to happen they have put her back on her own pump at 12 units per hour. This does not seem to have any effect. We are thinking hormones. We have ruled out insulin misuse as the doctors are monitoring and administering through the sliding scale. They have also tried injecting fast acting (NovoRapid) and 10 units has little or no effect. Do you have any ideas?


This is a an extremely unusual situation but does not make much sense. Surreptitious omission of insulin is always a high possibility under such circumstances but, if the insulin is really administered intravenously, then this is not very likely. There are not too many situations where insulin does not work intravenously except in extreme obesity and severe insulin resistance. I would hope that she is under the care of a certified diabetes specialist/endocrinologist - or can be transferred to such care - who can determine if antibodies to insulin have formed and what other possibilities to consider for such resistant states. Progressively increasing the insulin infusion doses usually works. Looking for other insulin resistance situations also, i.e., infections, adrenal excess, thyroid excess, etc., should be done, of course. Rarely, changing form one brand of insulin to another also may work.


Original posting 19 Feb 2011
Posted to Hyperglycemia and DKA and Daily Care


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