I understand that hyperglycemia is considered dangerous. As I also follow a medication program, I am confused about whether or not enhanced or added insulin is causing the down-regulation of insulin receptors and persisting hyperglycemia. It looks like my pancreas is secreting a lot of insulin and this, along with added insulin, is causing insulin resistance by down-regulating insulin receptors. It may also be causing decreased satiety resulting in increased cravings to overeat. Still, I consider myself a bit lucky by not having hyperlipidemia and maintaining hyperglycemia without serous diabetic related complications. Can this be correct?
Even though the use of insulin in type 2 diabetes is associated with some down-regulation of insulin receptors, it is usually potent enough to overcome this. Only those patients taking mega levels of insulin have such down-regulation that the insulin does not work. We occasionally see this in the hospital with patients on TPN (total parenteral nutrition) and in the face of another overwhelming medical problem.
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