Can we consider insulin resistance as a tolerance or resistance to previous excessive or increased exposure of sugar or/and insulin in type 2 diabetics? Is such previous excessive or more exposure common up to some stages after getting type 2 diabetes? As such, can decreasing excessive intake of foods, exercising, withdrawal of oral diabetic medicines and injected insulin for some time can help in reversing insulin resistance? I mean reversing insulin resistance, but not just normalizing of glucose level temporarily.
Resistance can happen both ways. For instance, patients with type 1 diabetes are insulin resistant. They are exposed to high insulin levels with exogenous insulin therapy. This results in down-regulation of insulin receptors. We routinely clamp patients with good control with type 1 diabetes and they have insulin resistance, compared to age-matched healthy subjects. People with type 2 diabetes have insulin resistance as a result of a post-receptor defect in insulin signal transduction. It is clear that short-term food restriction or weight loss will decrease insulin resistance. However, there is no eliminating insulin resistance as a pathophysiologic process. The property is genetic and can be seen in first degree relatives of people with type 2 diabetes who are otherwise healthy. It can be decreased with healthy lifestyle.
Original posting 15 Sep 2007
Posted to Type 2
|Return to the Top of This Page|
Last Updated: (none)
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2018. Comments and Feedback.