From Clifton, Colorado, USA:
My husband takes Amaryl along with insulin on a sliding scale basis according to what he eats, and yesterday he was low after lunch, but by dinner he was over 200 mg/dl [11.1 mmol/L]. How does Amaryl work? When does it peak? How long is it active?
Amaryl [glimepiride] is a second-generation long-acting sulfonylurea. It is taken once a day in the morning with the first meal and lasts about 24 hours. It works in people with type 2 diabetes by stimulating the beta cells in the pancreas to make more insulin.
You didn't say whether the insulin your husband took was long- or short-acting and what he had to eat and when, so there is no way I can evaluate why he had a low sugar mid-day and a high sugar later. Blood sugars levels in people with diabetes are greatly influenced by meals, physical activity, medication and stress. All of these factors have to be taken into consideration.
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