From Dallas, Pennsylvania, USA:
What effect does the use of growth hormone (Somatropin) have on the pancreas? Is it possible for overdosages to trigger type 1 diabetes earlier than it's naturally destined time frame? Could it affect somatostatin, the hormone made by the delta cells?
There is evidence that growth hormone levels tend to be somewhat high in type 1A (autoimmune), but that there is some degree of growth hormone resistance at the same time. This is perhaps why growth hormone administration does not seem to significantly hasten insulin dependence or to diminish control. Growth hormone does seem to promote type 2 diabetes, however.
Growth hormone and somatostatin both diminish glucose tolerance, but through different mechanisms. Somatostatin and its analogs like Octreotide have been used successfully in treating PHHI (Persistant Hyperinsulinemic Hypoglycemia of Infancy).
Original posting 18 Aug 2002
Posted to Other Medications
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