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Is Moduretic (a thiazide) or Atenolol (a beta blocker) contraindicated in Type 2 diabetes? I thought both of these would make blood sugars rise.


You are correct in supposing that both the thiazide drugs and the beta blockers without intrinsic sympathomimetic activity increase glucose intolerance in Type 2 diabetes. This is especially so when they are used together; but the problem can be circumvented by using ACE inhibitors as a first antihypertensive drug and by reducing the thiazide dose to as little as 6.25 mg hydrochlorothiazide a day. The mechanisms are complex, but you can find several reports by searching in PubMed.


Original posting 1 Jul 2000
Posted to Other Medications


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