From Carlisle, Pennsylvania, USA:
I was just wondering if they have found out which gene is responsible for diabetes. If they have, I would really appreciate knowing which one or if you could lead me in the right direction to find it.
Different forms of diabetes mellitus show different genetic patterns. In Type 1A or autoimmune diabetes, which is the commonest form in Caucasian children in North America, there is a genetically determined susceptibility to the disorder which has to be triggered by a so far unknown environmental component before insulin dependent clinical diabetes can develop. The several alleles that determine this predisposition are located in the Main Histocompatability Complex (MHC) region on the short arm of chromosome 6. Other loci on chromosomes 2, 11, 15 and 18 may also play a role. A more detailed description of all of this together with many references can be found in Chapter 7 of George Eisenbarth and Kevin Lafferty's book on Type 1 diabetes which you can find at www.uchsc.edu/misc/diabetes/oxch7.html. The text is somewhat technical though, so be prepared.
Original posting 20 Jun 2000
Posted to Genetics and Heredity
|Return to the Top of This Page|
Last Updated: (none)
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
© Children with Diabetes, Inc. 1995-2018. Comments and Feedback.