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From Arkansas, USA:

What is the ratio of type 1 to kids with MODY?


The incidence of diabetes varies a good deal geographically. It is about 3:1000 in young Caucasians in North America and Europe. It is double this in Scotland and Finland and essentially nonexistent amongst the Masai in Tanganyika. The variation is due in part to genetic makeup and in part to environment. Giving even an approximately accurate figure for the ratio to MODY (Maturity Onset Diabetes of the Young) is difficult for two important reasons. The first is that there are now at least five different forms of MODY and even in MODY2 there are many genetically different subvariants. Secondly, the commonest form of MODY (i.e. the onset of Type 2 Diabetes in young people) has reached almost epidemic proportions amongst populations that have become recently exposed to Western style living; the Canadian Eskimos are a good example. In these cases there is a clear link to obesity and the changed impact of the hormone Leptin on carbohydrate metabolism.


Original posting 3 May 1999
Posted to Diagnosis and Symptoms


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