What are anti-gad antibodies?
GAD stands for glutamic acid decarboxylase which is an enzyme common to all cells. When immunological damage to the insulin-producing islet cells begins, there is a release of this and other enzymes and antibodies are formed (anti-GAD). Anti-GAD together with anti-insulin antibodies and another antibody called ICA512 are used either to detect preclinical damage to the islet cells in Type 1A diabetes or to confirm that that is indeed the correct diagnosis. Many laboratories in doing this routine testing also look for anti-transglutaminase and anti-21-hydoxylase, markers of two other autoimmune conditions that are significantly, but not commonly, linked to Type 1A Diabetes.
Original posting 13 Sep 1998
Posted to Research: Causes and Prevention
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