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From Alberta, Canada:

Our youngest son, age 5 3/4, is exhibiting symptoms of Type 1 Diabetes. They are excessive urination and a 13.8 [248 mg/dl] blood sugar reading shortly after eating. Our oldest son, age seven, was diagnosed at age six with Type 1. The children's hospital in Calgary will be running tests tomorrow. The doctor has told us that if we are correct and he is developing diabetes there is nothing we can do. They say all Canadian studies on preventing the onset of diabetes in high risk patients by insulin injections have finished. They mentioned the U.S. as a possibility. Is it true that we can do nothing to prevent the further onset of Type 1 diabetes? Is there any U.S. research groups close to Alberta that we could take our son to or at least contact through our hospital here?


In view of the family history and the symptoms, it certainly seems as though your younger son is on the brink of overt clinical diabetes. On the basis though of only a single not very precisely defined blood sugar it is hard for me to decide whether he has actually become insulin dependent or whether he could still be called prediabetic. Assuming that the antibody test is positive for two or three of the antibodies usually tested you might like to discuss whether or not he is still a candidate for the U.S. study on early insulin administration either orally or by injection. The number to call for the DPT-1 study is 1-800-425-8361. The two centers that would be most readily accessible to you are Denver at 1-800-572-3992 or Minneapolis at 1-800-688-5252 x58944. It is possible that further tests would be needed to determine his eligibility; but if his doctor in Calgary thinks he is already insulin dependent then it would be true to say that trials of nicotinamide, BCG, etc., have been universally disappointing and are no longer in progress in the US either.


Original posting 7 Apr 1998
Posted to Research: Causes and Prevention


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