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From Kirkwood, Missouri, USA:

We have an adopted child from Korea. He is now 8 years old and weighs 93 pounds. Being adopted we have no medical history on him. We took him to an endocrinologist and also had his metabolism checked. All test came back negative. It was observed, though, that he has a dark neck in relation to the rest of his skin tone. We were told that this is a sign that he will be diabetic when older. Have you ever heard of this dark-neck diagnosis in Asian children?


The finding of dark color on the skin of the neck in your adopted overweight son from Korea could be a clue to a form of syndrome of clinical insulin resistance with acanthosis nigricans and postreceptor defect with glucose intolerance and marked resistance to exogenous insulin. The acanthosis nigricans is a dermatological disorder also present in association with other endocrine diseases (i.e., obesity, pituitary tumors, or Cushing's disease) and it is characterized by brown, velvety hyperkeratotic patches in the body folds. Very few cases have been reported so far and no one from Asia that I am aware of.


Original posting 10 Feb 98


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