From Williamsburg, Virginia, USA:
I wish I could find more information on insulin resistance and hyperinsulinemia.
The dictionary definition of Insulin Resistance is as follows:
Many people with noninsulin-dependent diabetes produce enough insulin, but their bodies do not respond to the action of insulin. This may happen because the person is overweight and has too many fat cells, which do not respond well to insulin. Also, as people age, their body cells lose some of the ability to respond to insulin. Insulin resistance is also linked to high blood pressure and high levels of fat in the blood. Another kind of insulin resistance may happen in some people who take insulin injections. They may have to take very high doses of insulin every day (200 units or more) to bring their blood glucose (sugar) down to the normal range. This is also called "insulin insensitivity."
It's very rare that people may need large doses of insulin (over 200 units) to control their diabetes. The problem with these individuals is not that they are overweight, but that their body makes antibodies that interfere with the insulin working properly. This may occur either after diabetes is diagnosed in response to injected insulin, or (in a rare form of diabetes) may actually be a cause of diabetes when the body makes antibodies against the "insulin receptor" - the part of the cell that must respond to the insulin.
Original posting 27 Aug 96
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