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Study Supports Use of Insulin Lispro in Pumps

In the May 5, 1999 issue of Diabetes Care, researchers from Germany published the results of a study that examined the efficacy and tolerability of Insulin Lispro [Humalog] in pumps. 113 patients with Type 1 diabetes who used an insulin pump participated in the open, randomized crossover study. Each used Regular or Insulin Lispro for four months. The study looked at HbA1c, daily and postprandial blood glucose profiles, adverse events, rate of hypoglycemic and hyperglycemic events, catheter obstructions, and patient statisfaction.

During the study, HbA1c levels decreased for all participants, but is was better during treatment with Insulin Lispro (Insulin Lispro: 6.8 +/- 0.9%, Regular: 6.9 +/- 1.0%). The one- and two-hour postprandial blood glucose rise was significantly lower when using Insulin Lispro. There were no significant differences in rates of hypoglycemia, catheter obstructions, or adverse events. Patients reported greater satisfaction when using Insulin Lispro.

Insulin Lispro is fast replacing Regular as the insulin of choice for users of pumps. [See our poll on insulin regimen.] This study supports the use of Insulin Lispro as a safe alternative to Regular.

[Diabetes Care 22:784-788, 1999]

Posted 16 May 1999

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