Persistent Hyperinsulinaemic Hypoglycaemia of Infancy (PHHI), also known as nesidioblastosis, is a rare, usually inherited condition in which the pancreas produces too much insulin. This is the exact opposite of what happens in type 1 diabetes, but care involves frequent blood sugar tests as with kids with diabetes.
Babies born with PHHI can have severely low blood sugar levels and seizures, and are at high risk for brain damage if blood sugar levels are not maintained at sufficiently high levels. Treatment can include medications, additional feedings, and even removal of up to 90-95% of the pancreas.
- The outcome in Australian children with hyperinsulinism of infancy: early extensive surgery in severe cases lowers risk of diabetes.
For More Information
- The Congenital Hyperinsulinism Center at The Children's Hospital of Philadelphia is a world-leading center for kids with PHHI
- Sur1 Hyperinsulinism, a web site by parents of kids with nesidioblastosis, is an excellent resource with extensive references
- Nesidioblastosis by Robert S. Gillespie, MD, and Stephen Ponder, MD, CDE
- Ask the Diabetes Team questions about nesidioblastosis
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